In reference interval transference studies, which reference limit percentage is described as acceptable?

In reference interval transference studies, which reference limit percentage is described as acceptable?

• A. 68%
• B. 90%
• C. 95%
• D. 99%

Answer: (A)

In reference interval transference studies, the goal is to determine whether the existing reference limits will remain appropriate when applied to a different assay, instrument, or population. The acceptable reference limit percentage is 68%, which reflects about one standard deviation around the mean in a normal distribution. This threshold recognizes typical analytical and biological variation and suggests that roughly two-thirds of healthy individuals would still fall within the transferred limits. Higher percentages (like 90%, 95%, or 99%) would imply too strict an alignment given the inherent differences between methods, making 68% a practical, widely used criterion for acceptable transfer.

In reference interval transference studies, the goal is to determine whether the existing reference limits will remain appropriate when applied to a different assay, instrument, or population. The acceptable reference limit percentage is 68%, which reflects about one standard deviation around the mean in a normal distribution. This threshold recognizes typical analytical and biological variation and suggests that roughly two-thirds of healthy individuals would still fall within the transferred limits. Higher percentages (like 90%, 95%, or 99%) would imply too strict an alignment given the inherent differences between methods, making 68% a practical, widely used criterion for acceptable transfer.