Which factor is applied to the Cockcroft-Gault equation to adjust for female sex?

Which factor is applied to the Cockcroft-Gault equation to adjust for female sex?

• A. 0.85
• B. 1.00
• C. 0.75
• D. 1.15

Answer: (A)

In Cockcroft-Gault, you adjust for female sex by multiplying the calculated creatinine clearance by 0.85. This correction accounts for typically lower muscle mass and creatinine production in women, making the estimate more accurate for female patients. So you compute CrCl with the standard formula and then apply CrCl_female = 0.85 × CrCl_male. The other numbers would either leave the result unchanged or apply an incorrect adjustment, which is why 0.85 is the correct factor.

In Cockcroft-Gault, you adjust for female sex by multiplying the calculated creatinine clearance by 0.85. This correction accounts for typically lower muscle mass and creatinine production in women, making the estimate more accurate for female patients. So you compute CrCl with the standard formula and then apply CrCl_female = 0.85 × CrCl_male. The other numbers would either leave the result unchanged or apply an incorrect adjustment, which is why 0.85 is the correct factor.